Coming Home

For easing newcomers in following along, please consult the glossary of terms that I’ve written to make the terminology very understandable. Also, consult the post that explains the essential background
We continue with our treatment of this paper from <strong>Part II.

One of the main components of this article’s investigation is the effect of Oral Contraceptive (OC) use on the development of Triple-Negative breast cancer. Induced abortion has only been one small component of the study. However, the data support the fundamental biological model of breast physiology, namely that high doses of estrogens stimulate breast lobule development, leading to a doubling of breast size and a dramatic increase in the number of immature, cancer-prone Type 1 & 2 cells which require the maturational effects of placental lactogen in the third trimester of pregnancy.

There were a great many parameters measured in the study, and AGAIN, I must stress that BC has MANY risk factors that are well known and well publicized. One need only visit Komen or ACS to see them. What they will not see is the ABC link, and the extent of the data on Oral Contraceptives (OC’s). That is our purpose here, to mine the data buried under a mountain of denials and distortions.

Again, refer to the glossary of terms for brief and user-friendly definitions of the statistical jargon.

All data were reported with 95% CI’s (meaning 95% certitude that the results were not due to chance). Using controls as reference values, the following Odds Ratios were established (meaning risk relative to the controls) OR’s of 2.0 mean a doubling of risk, 3.0 a tripling, 4.0 a quadrupling of disease incidence, etc.

{Fear not math phobes, it’s as simple as that!}

For patients with a family history of BC:

Triple-Negative Patients with a 1st Degree relative OR=3.5
Triple-Negative Patients with a 2nd Degree relative OR=1.8

Non-Triple-Negative Patients with a 1st Degree relative OR=2.8
Non- Triple-Negative Patients with a 2nd Degree relative OR=1.7

*We’ll return to these risks at a later date as regards abortion and family history.

For all breast cancer cases, triple-negative and non-triple-negative cases, in relation to oral contraceptive risk factors, stratified by age at diagnosis </=40

Oral Contraceptive Use (Year):

Triple-Negative Patients.

Never/<1year use. OR= 1.0 (Reference)
1+ year use. OR= 4.2

Non-Triple-Negative Patients

Never/<1year use. OR= 1.0
1+ year use. OR= 1.2

OC Duration (years):

Triple-Negative Pts.

1 to < 3 OR=3.0
3 to < 6 OR=4.9
6+ OR=4.7

Non-Triple-Negative Pts.

1 to < 3 OR=1.3
3 to < 6 OR=1.2
6+ OR=1.2

Age at First Use:

Triple-Negative Pts.

22+ OR=3.5
18 to <22 OR=3.7
<18 OR=6.4

Non-Trip. Neg. Pts

22+ OR=1.1
18 to <22 OR=1.1
<18 OR=1.8

Years Since 1st Use

Triple-Negative Pts.

<20 OR=4.2
20+ OR=4.2

Non-Triple-Negative Pts.

<20 OR=1.2
20+ OR=1.6

Years Since Last Use:

Triple-Negative Pts.

Current OR=4.5
1 to <10 OR=5.1
10 to 15 OR=4.2
15+ OR=2.1

Non-Triple-Negative Pts.

Current OR=0.8
1 to <10 OR=1.3
10 to 15 OR=1.4
15+ OR=1.2

These are simply devastating numbers. Considering how Planned Parenthood targets our daughters in their teen years and pumps them full of OC’s, this is just atrocious. Final analysis and commentary on this paper tomorrow.