Posts Tagged ‘Dr. Louise Brinton’

For ease newcomers following along , please consult the glossary of terms that I’ve written to make the terminology very understandable. Also, consult the post that explains the essential background
We continue with our treatment of this paper from Part I

The authors found a 40% increased risk in all forms of BC, as well as in triple negative BC. Based on this, there are some who say that this is proof of reporting or recall bias, as the percentages are the same across the board. There are a few responses to this argument.

First, It may well be that Oral Contraceptives (OC’s) contribute to BC by a different mechanism than does abortion. Estrogens in abortion and Oral Contraceptives (OC’s) stimulate the proliferation of breast tissue, doubling the number of immature cells that need the maturational effects of placental lactogen, which differentiates them into cancer resistant cells. However, the synthetic estrogens in OC’s are also implicated in the processes of tumor formation. That this study shows such dramatic increase in triple negative BC associated with OC use, compared to other forms of BC suggests a unique influence by the synthetic estrogens in the drug, as opposed to the natural estrogens. That isn’t to say that the natural estrogens are not also implicated, just that their effects may not be so marked as the synthetic estrogens.

Thus the mechanism by which disease is caused is not monolithic.

Next, it is a curiosity that the self-reports are only alleged to suffer from recall bias when they are about past abortions, and not OC use, or any other element of the health history. We saw a few days ago with Dr. Leslie Bernstein, 2003 NCI pro-abortion panelist, exactly where the actual bias resides when she said after the fraudulent “Fact Sheet” was issued:

“There are so many other messages we can give women about lifestyle modification and the impact of lifestyle and risk that I would never be a proponent of going around and telling them that having babies is the way to reduce your risk.”

{Editorial Note by GN: Bernstein says this in spite of all the data indicating that this is indeed the most significant means of reducing a woman’s risk.}

“I don’t want the issue relating to induced abortion to breast cancer risk to be part of the mix of the discussion of induced abortion, its legality, its continued availability. I think it should not be part of the argument.”

There are three “I’s” in there. Scientists are trained to step out of the spotlight when reporting the data and let the data speak for themselves. Here we see a scientist (speaking for the group?) who muzzled the data in order to allow her predilections take center stage. This is where the process gets corrupted. This is where the public is shielded from the truth because a self-appointed academic aristocracy decides what it is the public should and should not know about risk factors for disease, based upon a particular vision of social engineering.

Brinton and the rest of her like-minded colleagues may be sincere, but they are sincerely unethical and corrupt in publishing these data on the one hand, claiming in this paper that induced abortion is a known BC risk factor, and refusing to alter the NCI position paper from six years earlier which denies that link.

Further, Brinton, et al. returned to a 1990’s data set that they dismissed as contaminated by recall bias in 2003, and squeezed out another publication in 2009. They could have omitted the data on the ABC link in this 2009 paper, having already declared it invalid in 2003. They didn’t. It is impossible to speculate as to why they did not, as to why they listed induced abortion among the known BC risk factors. Any speculation as to motive is fruitless.

The fact remains that they have once again published a link. They have also reviewed and let stand (on January 12, 2010) their NCI position paper. Whatever their definition of women’s empowerment and how that may be negatively impacted relative to the realities of childbearing and rearing, the sight of a woman recovering from mastectomy, ravaged by radiation and chemotherapy, is hardly one that conjures an image of empowerment and hardly seems worth the trade.

The fact that Brinton, et al. don’t trust women with the information to discern that trade-off’s worth tells us everything we need to know about their brand of feminism. It is morally bankrupt, utterly untenable, and deeply hostile to women, children, and families. It is characterized by an arrogance and contempt so severe as to require the deliberate dismissal and distortion of over a half-century of scientific data regarding yet another deleterious consequence of abortion on women’s bodies, minds, and spirit.

It seems that the elitists of the feminist movement have imposed their own brand of chauvinism on their sisters, one with far deadlier and mutilatory consequences than the male chauvinism it replaced. Neither trusts women to deal with reality and organize their lives in a manner of their own choosing. Trading one set of chains for another is not liberation. The scientific data contain, both a validation of traditional moral norms and family life, as well as the way forward for any who care to stop and take an unbiased look.

In Part III, the frightening association between OC’s and triple negative BC.

This October, please consider $upporting the following who desperately need our $upport to get the truth out*:

Breast Cancer Prevention Institute

Coalition on Abortion/Breast Cancer

*I have no institutional affiliation or membership with either group. Karen Malec and BCPI have been great resources for me, utterly generous with their time and resources.

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For ease newcomers following along , please consult the glossary of terms that I’ve written to make the terminology very understandable. Also, consult the post that explains the essential background

Today’s paper is actually Saturday’s post. I seized a last minute opportunity to drive to Boston with my son to attend the BC-Notre Dame football game, and was busy all day yesterday. So today’s article, which covers a great deal of ground, will be considered in two posts to make the reading more manageable.

Title: Risk Factors for Triple-Negative Breast Cancer in Women
Under the Age of 45 Years

Authors: Jessica M. Dolle,1 Janet R. Daling,1 Emily White,1,3 Louise A. Brinton,4 David R. Doody,1 Peggy L. Porter,2 and Kathleen E. Malone1,3

Divisions of 1Public Health Sciences and 2Human Biology, Fred Hutchinson Cancer Research Center; 3Department of Epidemiology, University of
Washington, Seattle, Washington; and 4Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

Journal: Cancer Epidemiology Biomarkers and Prevention 2009;18(4): 1157-1166

The current study investigates the etiologic (causal) factors for triple negative breast cancer, which is an extremely aggressive form of the disease. The cancer cells are negative for estrogen receptor/progesterone receptor/human epidermal growth factor. I won’t be delving into the molecular biology of the disease in the posts in order to keep the focus of the project. However, we can discuss anything in the comments below.

The paper uses the data on patients from two previous population-based, case-control studies by the authors in the early 1990’s:

17. White E, Malone KE, Weiss NS, Daling JR. Breast cancer among
young United States women in relation to oral contraceptive use.
J Natl Cancer Inst 1994;86:505 – 14.

18. Daling JR, Malone KE, Voigt LF, White E, Weiss NS. Risk of breast
cancer among young women: relationship to induced abortion. J Natl
Cancer Inst 1994;86:1584 – 92.

“In-person interviews of comparable format, covering a broad range of risk factors that included lifestyle/demographic factors, reproductive history, and oral contraceptive use, were administered to participants in both studies. Tumor specimens were obtained for 1,019 of the 1,286 cases with invasive breast cancer who were accrued in the two previous studies. Tissue collection, pathology review, and testing for prognostic markers have been discussed previously.”

Tissue samples taken from the tumors in those women were frozen for future study and analyzed in the current study.

As we shall see in this 2009 paper, the risks for BC arising from induced abortion are consistent with earlier findings from the authors, and in the literature we have examined to date. In a sleight of hand that carries no merit in the scientific community, the authors seek to indemnify Dr. Louise Brinton from responsibility for the data refuting her NCI panel’s declaration that there is no credible link between induced abortion and BC. They note at the bottom of the first page:

“ Note: J.M. Dolle had full access to all of the data in the study and takes responsibility
for the integrity of the data and the accuracy of the data analysis.”

While it is true that in large collaborative studies such as this one not every author can rigorously argue and defend every aspect of the study, it is nevertheless accepted that signing one’s name to the submitted paper is an indication that one takes ownership of ALL the data and stated conclusions. Thus the disclaimer may well make Dolle the principle author for a defense of the end-product of data analysis, but Louise Brinton has given her implicit agreement with Dolle’s contribution, and is thus responsible for now placing herself in the untenable position of either needing to withdraw thia paper, or withdraw her 2003 NCI “Fact Sheet”.

The note does not simply direct questions about the data analysis to Dolle. It suggests that she bears the responsibility for the data analysis in a manner that is disproportionate to the ownership of that analysis by every author who subscribed their name.

In this study, the authors boast of its robust size (which is no larger than most of the other retrospective studies claiming an ABC link) as being a strength:

“We undertook this study to evaluate the contribution of known and suspected breast cancer risk factors to triple-negative breast cancer in a large population-based study.” (pg. 1158)

“Our study has the strength of being population based and is the largest of its kind to evaluate breast cancer subtypes and etiologic differences in young women.” (pg. 1165)

These are important claims, as the authors invalidate the critique suggestive that only huge prospective studies involving scores of thousands to hundreds of thousands of subjects have the strength of numbers for making claims such as an ABC link. Further, if the authors dismiss the self-reports of women as regards abortion, then why would they have cause to believe the integrity of those self-reports regarding anything else? The authors list the known risk factors for BC, including OC use and induced abortion:

“In analyses of all 897 breast cancer cases (subtypes combined), the multivariate-adjusted odds ratios for examined risk factors were consistent with the effects observed in previous studies on younger women (Table 1). Specifically, older age, family history of breast cancer, earlier menarche age, induced abortion, and oral contraceptive use were associated with an increased risk for breast cancer. Risk was decreased in relation to greater number of births and younger age at first birth. Oral contraceptive use >1 year was associated with a modest increased risk for breast cancer, and among oral contraceptive users only, earlier age at first use further elevated the risk.” (1162-1163)

This statement validates all that we have covered together up until this point in our analysis of the literature, and Dr. Louise Brinton has accepted ownership of this statement. We shall consider this all in greater detail in Part II.

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